| Variable | Hazard Ratio | 95% CI | p Value |
|---|---|---|---|
| Age | -- | ||
| ≤70 | 1c | 1.039 to 1.430 | -- |
| >70 | 1.219 | 0.015 | |
| Sex | |||
| Female | 1c | -- | -- |
| Male | 1.377 | 1.041 to 1.821 | 0.025 |
| Karnofsky Index | |||
| <70 | 1c | -- | -- |
| ³70 | 0.439 | 0.361 to 0.534 | <0.001 |
| Histology | |||
| Squamous cell Ca | 1c | -- | -- |
| Adenocarcinoma | 1.058 | 0.899 to 1.245 | 0.499 |
| Large cell/Undifferentiated | 1.240 | 1.000 to 1.537 | 0.05 |
| Stage | |||
| Ia-IIb | 1c | -- | -- |
| IIIa-IIIb | 2.550 | 2.058 to 3.158 | <0.001 |
| IV | 5.283 | 4.281 to 6.520 | <0.001 |
| Chemotherapy | |||
| No | 1c | -- | -- |
| Yes | 0.706 | 0.591 to 0,843 | <0.001 |
| Period | |||
| 1990-97 | 1c | -- | -- |
| 2003-05 | 0.670 | 0.563 to 0.797 | <.001 |