| Characteristics |
Before Match |
After Match |
| FP44 (N=2,294) |
MON (N=16,994) |
p-Value |
FP44 (N=2,212) |
MON (N=4,424) |
p-Value |
| Age, y, (mean, SD)*
|
7.2 (2.2) |
7.1 (2.2) |
0.004 |
7.2 (2.2) |
7.2 (2.2) |
0.616 |
| Female (%)*
|
40.4 |
39.3 |
0.348 |
40.6 |
40.6 |
0.964 |
| Region (%)*
|
| East |
33.0 |
29.9 |
0.027 |
33.2 |
34.5 |
0.185 |
| Midwest |
57.1 |
45.5 |
<0.001 |
56.5 |
56.2 |
0.727 |
| South |
4.1 |
14.7 |
<0.001 |
4.3 |
3.5 |
0.002 |
| West |
5.8 |
9.8 |
<0.001 |
6.0 |
5.9 |
0.843 |
| Season of index prescription(%)*
|
| Winter |
30.6 |
23.7 |
<0.001 |
29.8 |
30.6 |
0.362 |
| Autumn |
29.3 |
27.9 |
0.159 |
29.5 |
29.9 |
0.674 |
| Summer |
13.1 |
18.1 |
<0.001 |
13.5 |
12.8 |
0.314 |
| Spring |
26.9 |
30.2 |
0.001 |
27.3 |
26.7 |
0.552 |
| Physician specialty (%)*
|
| Specialist |
11.8 |
15.9 |
<0.001 |
12.3 |
11.7 |
0.433 |
| Primary care |
72.9 |
66.3 |
<0.001 |
72.5 |
70.8 |
0.078 |
| Others |
15.2 |
17.7 |
0.003 |
15.3 |
17.5 |
0.005 |
| Charlson index in pre-index period (mean, SD)*
|
0.98 (0.44) |
0.98 (0.39) |
0.718 |
0.98 (0.43) |
0.98 (0.36) |
0.804 |
| Concomitant allergic rhinitis (%)*
|
31.6 |
46.9 |
<0.001 |
32.2% |
31.2 |
0.162 |
| # of classes of AR medications (mean, SD) |
0.53 (0.75) |
0.61 (0.80) |
<0.001 |
0.54 (0.76) |
0.53 (0.75) |
0.387 |
| Presence of SABA use (%) |
71.3 |
43.4 |
<0.001 |
81.6 |
71.5 |
<0.001 |
| # of SABA canisters, (mean, SD)*
|
1.26 (1.63) |
0.75 (1.26) |
<0.001 |
1.29 (1.15) |
1.21 (1.61) |
<0.001 |
| Presence of OCS use (%) |
36.9 |
36.7 |
0.829 |
36.5 |
36.2 |
0.749 |
| # of OCS prescriptions, (mean, SD)*
|
0.53 (0.88) |
0.54 (0.88) |
0.628 |
0.53 (0.88) |
0.54 (0.91) |
0.378 |
| Hosp/ED for asthma-related conditions
(%)*
|
8.0 |
7.6 |
0.521 |
7.8 |
8.4 |
0.607 |
| Hosp/ED for asthma-related conditions
(mean, SD) |
0.09 (0.36) |
0.09 (0.34) |
0.397 |
0.09 (0.36) |
0.10 (0.37) |
0.314 |
|
Asthma-related costs in pre-index period |
| Medical costs (mean, SD) |
$260 (886) |
$245 (666) |
0.420 |
$259 (896) |
$275 (767) |
0.349 |
| Pharmacy costs (mean, SD) |
$41 (136) |
$40 (99) |
0.912 |
$39 (138) |
$42 (83) |
0.127 |
| Total costs (mean, SD) |
$301 (905) |
$285 (453) |
0.420 |
$297 (914) |
$318 (785) |
0.262 |
* Variables used for propensity matching. FP44 = Fluticasone propionate 44mcg, MON = montelukast, SD = standard deviation Hosp= hospitalizations, ED = emergency department visit, AR = allergic rhinitis, SABA = short acting beta agonists, OCS = oral corticosteroids.