Table 3.: Trials Comparing Different Natural Surfactants

Year Authors Surfactants Used Participants Endpoints of Trial Results of Trial
1997 Bloom et al. [47]
  1. Beractant
  2. Calfactant
 374 (prevention arm)
608 (treatment arm)
BW<2000g
  1. Short-term outcome
  2. Neonatal morbidity
  3. Neonatal mortality
 Calfactant had better short-term outcome
both in prevention and treatment arms
No difference in other endpoints
2004 Attar et al. [46]
  1. Beractant
  2. Calfactant
 40
<37 weeks GA
  1. Short-term outcome
  2. Neonatal mortality
 Calfactant had better short-term outcome
No difference in neonatal mortality
2005 Bloom et al. [48]
  1. Beractant
  2. Calfactant
 740 (prevention arm)
1361 (treatment arm)
BW 401-2000g
  1. Short-term outcome
  2. O2 requirement at 36 weeks
  3. Mortality rate
 Calfactant had better short-term outcome
Other endpoints same
1995 Speer et al. [52]
  1. Beractant
  2. Poractant
 73
BW 700-1500g
  1. Short-term outcome
  2. Pneumothorax
  3. CLD at 36 weeks
  4. Mortality rate
 Poractant had better short-term outcome
Other endpoints same
2003 Baroutis et al. [49]
  1. Beractant
  2. Poractant
 53
<32 weeks GA
BW<2000g
  1. Short-term outcome
  2. Air leaks
  3. O2 requirement at 36 weeks
  4. Mortality rate
 Poractant had better short-term outcome
Other endpoints same
2004 Ramanathan et al. [51]
  1. Beractant
  2. Poractant Low dose 100mg/kgHigh dose 200mg/kg
 293
<35 weeks GA
BW 750-1750g
  1. O2 requirement at first 6 hours after dosing
  2. Pneumothorax
  3. O2 requirement at 36 weeks
  4. Mortality rate
 High-dose poractant lower mortality rate
Other endpoints same
2005 Malloy et al. [50]
  1. Beractant
  2. PoractantHigh dose 200mg/kg
 60
<37 weeks GA with RDS
  1. Pneumothorax
  2. BPD at 36 weeks
  3. Mortality rate
 No difference in endpoints
2011 Singh et al. [53]
  1. Beractant
  2. PoractantLow dose 100mg/kgHigh dose 200mg/kg
 529
<37 weeks GA with RDS
  1. O2 requirement at 36 weeks
  2. Need for re-dosing
  3. Short-term outcome
  4. Mortality rate
 Poractant reduced need of re-dosing, improved short-term outcome, and decreased mortality
O2 requirement at 36 weeks same for both groups
2011 Ramanathan et al. [54]
(Retrospective study)
  1. Beractant
  2. Poractant
  3. Calfactant
 14,173
<37 weeks GA with RDS		 Mortality rate Poractant significantly reduced mortality as compared to calfactant
Poractant non-significantly reduced mortality as compared to beractant