Fig. (1) MSC-CM protection against cytokine-driven reductions in islet cell viability. Following exposure to increasing concentrations of IFN-γ, TNF-α or IL-1β for 24 h, the cellular viability of BRIN-BD11 cells, βTC1.6 cells and primary islets grown in standard non-conditioned medium (NCM) or MSC-conditioned medium (CM) was assessed by colorimetric MTT assay. Data are normalized to untreated controls and presented as mean ± standard deviation (SD). n=4 with all experiments assayed in duplicate. *P<0.05, **P<0.01, ***P<0.001 and ****P<0.0001 compared with non-conditioned media. MSC-CM, Mesenchymal Stem Cell Conditioned Medium; IFN-γ, Interferon gamma; TNF-α, tumour necrosis factor alpha; IL-1β, Interleukin 1 beta.