Fig. (6) Recombinant IL-10 protects against IFN-γ and TNF-α-driven reductions in cellular viability. The viability of BRIN-BD11 and βTC1.6 cells was assessed by calorimetric MTT assay after exposure to IFN-γ, TNF-α, or IL-1β ± rising concentrations of IL-10 as indicated in the Figure. Data are normalized to untreated controls and presented as mean ± standard deviation (SD). N=4 with all experiments assayed in duplicate. **P<0.01 and ***P<0.001. IFN-γ, Interferon gamma; TNF-α, tumour necrosis factor alpha; IL-1β, Interleukin 1 beta; IL-10, Interleukin 10.