Fig. (8) MSC-CM protection against beta cell susceptibility to IFN-γ or TNF-α challenge is IL-10-dependent The viability of BRIN-BD11 (A) and βTC1.6 cells (B) was assessed by colorimetric MTT assay after the addition of 100 ng/ml of anti-IL-10 ± IFN-γ or TNF-α. Data are normalized to untreated controls and presented as mean ± standard deviation (SD). n=3 with all experiments assayed in duplicate. **P<0.01 and ***P<0.001 compared with corresponding non-conditioned media control (i.e., RMPI or DMEM). MSC-CM, Mesenchymal Stem Cell Conditioned Media; IFN-γ interferon gamma, TNF-α tumour necrosis factor alpha.