Table 1: Melanoma virotherapy.

Virus Modifications Experimental Clinical trials References
Herpes simplex virus T-vec ICP34.5 deletion, US11deletion,
GM-CSF insertion		 + + 14, 15, 16, 65, 117
HF10 UL56 deletion + + 161
IL-2 insertion + - 129
Vaccinia virus JX-594 GM-CSF insertion, TK deletion + + 14, 66, 117
Reovirus Reolysin None + + 152
Coxsackie virus Cavatak None + + 162
Adenovirus Tyrosinase promoter/enhancer insertion + - 84
IL-18 insertion + - 107
IL-12 and B7 insertion + - 123
Decorin insertion + - 102
Vesicular stomatitis virus Insertion of TAAs from melanoma cDNA library + - 115
CD40L insertion + - 121
Influenza virus NS1 deletion + - 93
Newcastle disease virus IL-2 insertion + - 127, 128
Measles virus Encoding anti-CTLA-4 and anti-PDL1 + - 126
Retrovirus Insertion of anti-HMWMAA + - 75, 76, 77

Abbreviations: CD, cluster of differentiation; CTLA, cytotoxic T-lymphocyte antigen; GM-CSF, granulocyte monocyte colony-stimulating factor; HMWMAA, high molecular weight melanoma-associated antigen; ICP, infected cell protein; IL, interleukin; NS, non-structural; PDL, programmed death receptor; TAA, tumor associated antigen; ligand; TK, thymidine kinase; US, unique short.